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The role of the ma- jor intrastrand d(GpG) adducts is not fully understood; however, structu- ral perturbations in DNA may play a key role in the antitumor activity of cisplatin [16]. 58 4. Shattuck, in Proceedings of La Jolla Conference on Categorical Algebra, New York, Springer-Verlag, 1966, pp.


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